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- Title
Kinetic tools for the identification of ligand--receptor interaction mechanisms.
- Authors
Kukk, Siim; Miidla, Peep; Järv, Jaak
- Abstract
Tools for the identification of ligand-receptor interaction mechanisms were developed by mathematical modeling of the influence of a ligand on the kinetics of a reporter ligand binding with a receptor. This approach allows kinetic differentiation between ligands of both rapid and slow binding modes, but also distinguishes compounds that share the same binding site with the reporter ligand or bind non-competitively to a distinct binding site. In order to simulate the kinetic behavior of this system, a mathematical model comprising ordinary differential equations was derived and solved numerically.
- Subjects
LIGAND binding (Biochemistry); RECEPTOR-ligand complexes; DRUG receptors; ISOMERIZATION; PHYSICAL &; theoretical chemistry; MATHEMATICAL models
- Publication
Proceedings of the Estonian Academy of Sciences, 2017, Vol 66, Issue 2, p202
- ISSN
1736-6046
- Publication type
Article
- DOI
10.3176/proc.2017.2.08