We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Posttransplant hypertension: Studies of cortical blood flow and the renal pressor system.
- Authors
Bennett, William M.; McDonald, Walter J.; Lawson, Russell K.; Porter, George A.
- Abstract
Thirteen hypertensive and six normotensive posttransplant patients were studied 6 to 28 months after grafting. No significant differences in prednisone dosage incidence of pretransplant hypertension, remaining diseased kidneys, glomerular filtration rate, type of donor or original renal disease existed between groups. Using a 133Xe-xenon washout technique, hypertensive patients had lower mean renal blood flow, 130 + 18 ml: 100 g/min, and cortical blood flow, 211+15 ml/100 g/min, than the 260±24 and the 414± 37 ml/100 g/min, respectively, (P<0.01) recorded in the normotensive group. There was no significant difference in intrarenal blood flow distribution between the groups. Transplant vein renin activity was significantly greater in hypertensive patients on a l0-mEq sodium diet. 22.71 ± 6.2 ng/ml/hr, than in the normotensive group. 4.89 ± 1.1 ng/ml/hr, on a similar sodium intake (P< 0.05), while urinary aldosterone excretion was elevated in both groups. Renin activity and aldosterone excretion could he suppressed into the normal range by high salt diet. Four instances of transplant artery stenosis were found in the 13 hypertensive patients by angiography, while 8 of the remaining 9 patients had pathologic evidence of intrarenal vascular or parenchymal disease, or both. Posttransplant hypertension should be actively investigated with controlled sodium intake so that proper medical or surgical therapy can be implemented.
- Subjects
KIDNEY transplantation; HYPERTENSION; BLOOD flow; GLOMERULAR filtration rate; KIDNEY function tests; KIDNEY glomerulus
- Publication
Kidney International, 1974, Vol 6, Issue 1, p99
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1974.85