We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of safety and efficacy of intragastric botulinum toxin-A versus gastric balloon.
- Authors
Tayyem, Raed; Qandeel, Haitham; Al-Balas, Hamzeh; Tayyem, Farah; Fataftah, Jehad; Al-Balas, Mahmoud
- Abstract
Background: A prospective case-matched study was conducted to compare the safety and efficacy of endoscopic intragastric botulinum toxin-A (EIBT) versus endoscopically planned gastric balloon (EPGB), as a treatment for obesity. Methods: A total of 176 patients (matched for age and sex) were equally divided to undergo EIBT (n = 88) or EPGB (n = 88). Patients who received EIBT were restricted to a body mass index (BMI) of 25 to 35 kg/m2, whereas a BMI >25 kg/m2 was allowed in the EPGB group. The main measured outcomes were weight loss, procedure duration, complications, early satiety, and quality of life (QoL). Results: The patients were followed up for a mean of 6 months. The mean weight loss was greater in the EPGB group than in the EIBT group (15.6 kg vs. 9.3 kg, P < 0.001). However, the percentage excess weight loss and the satiety score were greater in the EIBT group (59.1% vs. 42.2%, P < 0.001; and 3.5 vs. 2.3, P < 0.001) respectively. The procedure duration was shorter for EIBT patients (10 min vs. 15 min, P < 0.001). The postoperative complication rate recorded in the EPGB group was significantly higher (30% vs. 9%, P = 0.001). Adverse symptoms lasted longer in EPGB (5.2 days vs. 0.7 days, P < 0.001). Both groups enjoyed similar improvements in QoL. Conclusion: EIBT is a safe and effective treatment for mild obesity. Although the weight loss was greater in the EPGB group, the percentage excess weight loss, procedure duration, postoperative complications, and symptom duration were significantly better in the EIBT group. QoL improvement was comparable between the two groups.
- Subjects
BARIATRIC surgery; BOTULINUM toxin; OBESITY; DRUG efficacy; CLINICAL trials; TREATMENT duration; SATISFACTION; SURGICAL complications; TREATMENT effectiveness; COMPARATIVE studies; WEIGHT loss; QUALITY of life; DESCRIPTIVE statistics; BODY mass index; LONGITUDINAL method; EVALUATION
- Publication
Saudi Journal of Gastroenterology, 2022, Vol 28, Issue 4, p276
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/sjg.sjg_534_21