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- Title
Association of Plasminogen Activator Inhibitor-1 Gene Polymorphism with Inflammatory Bowel Disease in Iranian Azeri Turkish Patients.
- Authors
Shaghaghi, Zeynab; Bonyadi, Mortaza; Somi, Mohammad H.; Khoshbaten, Manouchehr
- Abstract
Background/Aim: Previous studies have shown the association of some genetic factors, such as Plasminogen activator inhibitor type-1 (PAI-1) 4G/5G polymorphism, with the development of inflammatory bowel disease (IBD). We aimed to study this polymorphism as a risk factor in IBD patients in this cohort. Patients and Methods: One hundred and fifteen IBD patients and 95 healthy controls were selected from Iranian Azeri Turks and -6754G/5G polymorphism of PAI-1 gene was tested by polymerase chain reaction using allele-specific primers confirmed by sequencing. Results: There was no significant difference of PAI-1 polymorphism between IBD patients and the control group (P > 0.05). Furthermore, these data showed no significant difference between Crohn's disease and ulcerative colitis patients. However, 4G/4G homozygotes have reduced probability to progression of loss of appetite, whereas 5G/5G genotypes have increased risk for development of chronic diarrhea without blood, nausea, and loss of appetite. Conclusions: Although our study showed no significant association of PAI-1 polymorphism between patients and control group, the carriers of 4G/4G genotype and 4G allele had reduced risk for the progression of IBD features in this cohort.
- Subjects
IRAN; TURKEY; CHI-squared test; CONFIDENCE intervals; EPIDEMIOLOGY; FISHER exact test; GENETIC polymorphisms; INFLAMMATORY bowel diseases; POLYMERASE chain reaction; QUESTIONNAIRES; RESEARCH funding; DATA analysis; CASE-control method; DATA analysis software; SYMPTOMS; GENETICS
- Publication
Saudi Journal of Gastroenterology, 2014, Vol 20, Issue 1, p54
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.126322