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- Title
Application of the Essential Oil from Copaiba (Copaifera langsdorffii Desf.) for Acne Vulgaris: a Double-Blind, Placebo Controlled Clinical Trial.
- Authors
Gomes da Silva, Ary; de Freitas Puziol, Paula; Nunes Leitão, Roane; Gomes, Tatiana Rafaela; Scherer, Rodrigo; Lacerda Lopes Martins, Mônica; Scárdua Saade Cavalcanti, Áurea; Cavalcanti, Luiz Carlos
- Abstract
Copaiba oil-resin is widely used in traditional medicine due to its anti-inflammatory, healing, and antiseptic activities. This research aims to extract and evaluate the qualitative and quantitative composition of copaiba essential oil from the oil-resin, and test its effects, after incorporation in a gel applied in volunteers with acne, in a double-blind placebo controlled clinical trial. The essential oil was extracted by steam distillation, and purified by freezing to remove the residual remnant water. The density of the essential oil was g ravi metrically determined by weighing 1 mL of liquid at 20°C The identification of the essential oil components was carried out through high-resolution gas chromatography analysis, coupled with mass spectrometry. The essential oil has a density of 0.9175 mg/mL and was composed of 48 substances, 14 of which were the major components representing 95.80% of total essential oil composition. Cis-thujopsene was the main component (46.96% of total essential oil composition). The surface affected with acne decreased when treated with placebo (F = 13.931, p = 0.001, r = 0.518; r2 = 0.268), but the linear model could explain only 26.8% of total variance in original data matrix. There was a highly significant decrease in the surface affected with acne in the areas treated with the 1.0% copaiba essential oil preparation (F = 86.494, p = 0.000, r = 0.834; r2 = 0.695).
- Subjects
BRAZIL; THERAPEUTIC use of essential oils; MEDICAL botany; CHROMATOGRAPHIC analysis; CLINICAL trials; MASS spectrometry; PROBABILITY theory; REGRESSION analysis; STATISTICS; U-statistics; DATA analysis; ACNE; BLIND experiment; DATA analysis software; DESCRIPTIVE statistics
- Publication
Alternative Medicine Review, 2012, Vol 17, Issue 1, p69
- ISSN
1089-5159
- Publication type
Article