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- Title
A Combination Therapy of Methotrexate and Xianling Gubao Capsule for Female Patients with Moderate to Severe Active Rheumatoid Arthritis and its Impact on Ovarian Function.
- Authors
Fang Chen; Yingfang Wang; Chen Xu; Hongwei Du; Liuqing Wang
- Abstract
Rheumatoid arthritis is a common immune disease with early symptoms of joint swelling, morning stiffness, pain, and swelling. It could develop into a joint deformity as the disease progresses, resulting in the loss of normal joint function and seriously affecting the patient's quality of life. Methotrexate is the "anchor drug" for rheumatoid arthritis treatment, which has an immunosuppressive effect and could effectively prevent the abnormal activation of B cells in vivo, inhibit the abnormal generation of cytokines, and relieve related symptoms. However, in some cases, methotrexate alone is not ideal and often needs to be combined with other drugs like xianlinggubao capsules. This study has provided an experimental basis for the combined efficacy of methotrexate and xianlinggubao capsules for female patients with moderate to severe rheumatoid arthritis and their impact on ovarian function.
- Subjects
OVARIAN physiology; DISEASE progression; CYTOKINES; HERBAL medicine; B cells; IN vivo studies; PHARMACEUTICAL encapsulation; JOINT diseases; INFLAMMATION; WOMEN; ANTIRHEUMATIC agents; METHOTREXATE; TREATMENT effectiveness; RHEUMATOID arthritis; QUALITY of life; RESEARCH funding; COMBINED modality therapy; CHINESE medicine; THERAPEUTICS
- Publication
Current Topics in Nutraceutical Research, 2023, Vol 21, Issue 4, p434
- ISSN
1540-7535
- Publication type
Article
- DOI
10.37290/ctnr2641-452X.21:434-439