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- Title
Establishment and maintenance of blood–lymph separation.
- Authors
Janardhan, Harish P.; Trivedi, Chinmay M.
- Abstract
Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extravasated interstitial fluid, also known as lymph, into the venous system at the bilateral lymphovenous junctions. Recent advances revealed that lymphovenous valves and platelet-mediated hemostasis at the lymphovenous junctions maintain life-long separation of the blood and lymphatic vascular systems. Here, we review murine models that exhibit failure of blood–lymph separation to highlight the novel mechanisms and molecular targets for the modulation of lymphatic disorders. Specifically, we focus on the transcription factors, cofactors, and signaling pathways that regulate lymphovenous valve development and platelet-mediated lymphovenous hemostasis, which cooperate to maintain blood–lymph separation.
- Subjects
CARDIOVASCULAR system; LYMPHATICS; GREEK literature; MEDICAL literature; EXTRACELLULAR fluid
- Publication
Cellular & Molecular Life Sciences, 2019, Vol 76, Issue 10, p1865
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-019-03042-3