We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of two chlorhexidine - alcohol-based skin disinfectants in blood donation setting.
- Authors
So, B. K. L.; Chu, C. C. Y.; Ho, P. L.; Chow, K. H.; Leung, J. N. S.; Lee, I. Y. M.; Lin, C. K.; Lee, C. K.
- Abstract
Background Source reduction is important in minimizing bacterial-contaminated risk of blood products, but previous evaluation of chlorhexidine ( CHX) was confounded by inability of Tween and lecithin to neutralize CHX. The study aims to address this limitation and also evaluates the effectiveness of two CHX-alcohol-based skin disinfectants in blood donation setting. Methods A two-stage observational study was conducted. A single step 2% chlorhexidine gluconate/70% isopropyl alcohol brush ( CHX/ IPA-1) was first compared with current skin disinfection procedure consisting of sequential application of 10% povidone-iodine and 70% isopropyl alcohol ( PI/ IPA). Standard plates with conventional neutralizers (0·3% Tween-80, 0·1% lecithin) were used to enumerate residual bacterial counts. Then, CHX/ IPA-1 was compared with another applicator CHX/ IPA-2 with identical disinfectant contents using in-house plates with neutralizers (3% Tween-80, 0·3% lecithin, 0·1% histidine, 0·5% sodium thiosulphate, 3% saponin, 1% ether sulphate) having enhanced ability to neutralize CHX. Results All three products were found to reduce plate counts by > 2 log10 after disinfection. The CHX/ IPA-1 group gave fewer residual bacterial growth on standard plates than PI/ IPA group (5·9% vs. 61·7%, P < 0·001). With the use of in-house plates, residual bacterial growth was of no difference in both CHX/ IPA-1 and CHX/ IPA-2 groups (42·5% vs. 49·4%, P = 0·26). Conclusion Good efficacy was observed with one-stage application of CHX/ IPA in predonation skin disinfection and it could replace PI/ IPA. However, the efficacy of CHX/ IPA could be grossly overestimated in testing with standard plates because of insufficient neutralization.
- Subjects
SKIN disinfection; CHLORHEXIDINE; DIRECTED blood donations; BLOOD alcohol; ISOPROPYL alcohol; BLOOD platelets
- Publication
Vox Sanguinis, 2014, Vol 106, Issue 4, p316
- ISSN
0042-9007
- Publication type
Article
- DOI
10.1111/vox.12107