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- Title
Impact of the supplementation of melatonin on oxidative stress marker and serum endothelin-1 in patients with metabolic syndrome.
- Authors
Ghaderi-Zefrehi, Hossein; Seif, Faezeh; Niayesh‐Mehr, Reyhaneh; Ayashi, Saleh; Jafarirad, Sima; Niknam, Zahra; Rafiee, Mohammad Hessam; Babaahmadi‐Rezaei, Hossein
- Abstract
Objective: Metabolic syndrome (MetS) is characterized by the cluster of risk factors associated with diabetes and cardiovascular diseases. Given the influential role of oxidative stress (OxS) in the pathogenesis of MetS and the antioxidant properties of melatonin, our study aims to investigate the impact of melatonin supplementation on OxS biomarkers and serum endothelin-1 (ET-1) levels in patients diagnosed with MetS. Methods: This double-blind, placebo-controlled, randomized clinical trial involved male and female adult participants with MetS. Subjects in the melatonin and control groups were administered 6 mg/day of encapsulated powdered melatonin or placebo (wheat flour), respectively, over a 12-week period. We evaluated serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) activity, and ET-1 in MetS patients, both pre- and post-intervention. Results: Melatonin supplementation significantly decreased serum ET-1 level (1.55 ± 0.24 pg/ml vs. 0.808 ± 0.18 pg/ml; p = 0.04) and MDA (1.326 ± 0.05 μM vs. 1.134 ± 0.05 μM; p = 0.021) in the melatonin group relative to baseline values. Additionally, SOD activity displayed a significant increase (23.64 ± 2.77 U/ml vs. 41.35 ± 1.22 U/ml; p = 0.0001) in the melatonin group when compared to baseline. Conclusion: Our research indicates that 12 weeks of melatonin supplementation in MetS patients leads to a significant reduction in serum ET-1 and MDA levels, alongside an increase in SOD activity levels relative to baseline. However, further comprehensive and well-structured randomized controlled trials are essential for establishing the effects of melatonin supplementation on OxS biomarkers in diverse age demographics.
- Subjects
METABOLIC syndrome diagnosis; SUPEROXIDE dismutase; CARDIOVASCULAR diseases; RESEARCH funding; STATISTICAL sampling; BLIND experiment; MELATONIN; OXIDATIVE stress; DESCRIPTIVE statistics; RANDOMIZED controlled trials; METABOLIC syndrome; DRUG efficacy; ENDOTHELINS; BIOMARKERS; MALONDIALDEHYDE; DIABETES
- Publication
International Journal of Diabetes in Developing Countries, 2024, Vol 44, Issue 3, p619
- ISSN
0973-3930
- Publication type
Article
- DOI
10.1007/s13410-023-01266-5