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- Title
Hypothalamic-immune interactions: neuromodulation of natural killer activity by lesioning of the anterior hypothalamus.
- Authors
Cross, R. J.; Markesbery, W. R.; Brooks, W. H.; Roszman, T. L.
- Abstract
Placement of bilateral electrolytic lesions in the preoptic-anterior hypothalamic area (AHT) of Fischer 344 rats results in decreased splenic NK activity as compared to control and normal animals. Animals with AHT lesions have a decrease in NK activity 4 and 7 days after lesion placement, with a return to normal activity by day 14. Fractionation of spleen cells on glass bead columns results in non-adherent and adherent cell fractions with NK activity. ANT lesions affect 14K activity only in the adherent cell fraction.
- Subjects
IMMUNE response; HYPOTHALAMUS; CELL fractionation; IMMUNOLOGY; ANTIGEN-antibody reactions; SPLEEN
- Publication
Immunology, 1984, Vol 51, Issue 2, p399
- ISSN
0019-2805
- Publication type
Article