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- Title
Application of whole-lesion intravoxel incoherent motion analysis using iZOOM DWI to differentiate malignant from benign thyroid nodules.
- Authors
Song, Ming-hui; Jin, Yan-fang; Guo, Jin-song; Zuo, Lili; Xie, Hong; Shi, Kaining; Yue, Yun-long
- Abstract
Background: Intravoxel incoherent motion (IVIM) parameters derived from iZOOM diffusion-weighted imaging (DWI) can be used to quantitatively identify malignant thyroid nodules. However, the criteria are not standardized. Purpose: To determine IVIM parameter values derived from iZOOM DWI that can differentiate malignant from benign thyroid nodules. Material and Methods: Forty-two patients with 46 pathologically confirmed thyroid nodules. All patients underwent preoperative examinations with conventional and iZOOM DWI. A three-dimensional region of interest was drawn on multiple slices to cover the entire nodule. IVIM parameters (D, pure diffusion; f, perfusion fraction; and D*, pseudodiffusion) were measured. The IVIM parameters of the malignant and benign thyroid nodules were compared using independent samples t - tests, a multiple logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: D, D*, and f exhibited good reproducibility. The D and f values in the malignant nodules (D = [0.72 ± 0.14] × 10−3 mm2/s, [29.94 ± 7.36] %) were significantly lower than those in benign nodules (D = [1.23 ± 0.35] × 10−3 mm2/s, [36.00 ± 8.35] %). The D value achieved the highest area under curve (0.939). The optimal cut-off value for D was 0.87 × 10−3 mm2/s (sensitivity = 95.83%, specificity = 90.91%, positive predictive value [PPV] = 92.00%, negative predictive value [NPV] = 95.24%, and accuracy rate = 93.48%). The area under ROC curve (AUC) of D combined with the f value did not significantly differ from that of D. Conclusion: IVIM parameter D derived from iZOOM DWI may be helpful in differentiating malignant from benign thyroid nodules.
- Publication
Acta Radiologica, 2019, Vol 60, Issue 9, p1127
- ISSN
0284-1851
- Publication type
Journal Article
- DOI
10.1177/0284185118813599