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- Title
15-Deoxy-∆-<sup>12,14</sup>-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism.
- Authors
Li, Jingjing; Guo, Chuanyong; Wu, Jianye
- Abstract
15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years. By triggering the PPAR-γ signalling pathway, it plays many roles and exerts antitumour, anti-inflammatory, antioxidation, antifibrosis, and antiangiogenesis effects. Although many synthetic PPAR-γ receptor agonists have been developed, as an endogenous product of PPAR-γ receptors, 15d-PGJ2 has beneficial characteristics including rapid expression and the ability to contribute to a natural defence mechanism. In this review, we discuss the latest advances in our knowledge of the biological role of 15d-PGJ2 mediated through PPAR-γ. It is important to understand its structure, synthesis, and functional mechanisms to develop preventive agents and limit the progression of associated diseases.
- Subjects
SYNTHETIC receptors; PEROXISOME proliferator-activated receptors; DISEASE progression; DISEASE complications
- Publication
PPAR Research, 2019, p1
- ISSN
1687-4757
- Publication type
Article
- DOI
10.1155/2019/7242030