We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reduction of hydrobenzamides: a strategy for synthesizing benzylamines.
- Authors
Gonzalez-Oñate, Andrés; Quevedo, Rodolfo
- Abstract
Indirect reductive amination of aromatic aldehydes was studied in this work; aqueous ammonia was used as a nitrogen source. The results showed that aromatic aldehydes' reaction with aqueous ammonia produced compounds known as hydrobenzamides (N,N´-(phenylmethylene)bis(1-phenylmethanimines), having good yield. The reaction of hydrobenzamides with sodium borohydride reduced both imine and aminal carbons and produced a primary and secondary benzylamine mixture. This article analyses such behaviour and proposes a possible mechanism for explaining such transformation. The reaction of aromatic aldehydes with aqueous ammonia produced compounds known as hydrobenzamides (N,N´-(phenylmethylene)bis(1-phenylmethanimines). The reaction of hydrobenzamides with sodium borohydride reduced both imine and aminal carbons and produced a primary and secondary benzylamine mixture.
- Subjects
BENZYLAMINES; AMMONIA compounds; AMINATION; AROMATIC aldehydes; SODIUM borohydride; BENZYLAMINE; AMMONIA; LITHIUM borohydride
- Publication
Journal of Chemical Sciences, 2024, Vol 136, Issue 2, p1
- ISSN
0974-3626
- Publication type
Article
- DOI
10.1007/s12039-024-02259-5