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- Title
Multifaceted Roles of Transposons in Mammalian Evolution and the Future of Transposon Research.
- Authors
Kei Fukuda
- Abstract
This article, published in Genes & Genetic Systems, explores the multifaceted roles of transposons in mammalian evolution and the future of transposon research. Transposons, once considered "junk DNA," are now recognized as playing a pivotal role in species' evolution. They function in various forms, including DNA, RNA, and proteins, and contribute to the host's evolution by acquiring new functions over long evolutionary processes. However, the runaway of these functions can lead to various abnormalities, including aging, cancer, mental disorders, and autoimmune diseases. The article provides an overview of transposon functions and introduces new methodologies for studying them. It also highlights the importance of proper transposon regulation in the context of mammalian immune function and the connections between transposons and diseases. The article concludes by emphasizing the ongoing research on transposons and its potential for breakthroughs in genetics, biology, and disease prevention.
- Subjects
TRANSPOSONS; NON-coding DNA; RNA regulation; GENE regulatory networks; VIRAL genomes; CELL fusion
- Publication
Genes & Genetic Systems, 2023, Vol 98, Issue 6, p287
- ISSN
1341-7568
- Publication type
Article
- DOI
10.1266/ggs.98.287