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- Title
Pull and push: Talin activation for integrin signaling.
- Authors
Wang, Jia-huai
- Abstract
The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival. The specific binding to the cytoplasmic tail of integrin's β subunit by the intracellular protein talin is the key step of inside-out signaling. A 'pull-push' mechanism has been proposed to explain how the PIP2-enriched membrane disrupts the dual auto-inhibition of the N-terminal talin-FERM domain by the C-terminal talin-rod domain such that activated talin-FERM can reach the β-tail for integrin activation.
- Subjects
TALINS (Proteins); INTEGRIN-binding proteins; CELLULAR signal transduction; LIGAND binding (Biochemistry); CELL receptors; CYTOPLASM
- Publication
Cell Research, 2012, Vol 22, Issue 11, p1512
- ISSN
1001-0602
- Publication type
Article
- DOI
10.1038/cr.2012.103