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- Title
Low Plasma Adiponectin Concentrations Predict Increases in Visceral Adiposity and Insulin Resistance.
- Authors
Han, Seung Jin; Boyko, Edward J; Fujimoto, Wilfred Y; Kahn, Steven E; Leonetti, Donna L
- Abstract
<bold>Context: </bold>Plasma adiponectin concentration has been shown to be inversely associated with body mass index (BMI) and insulin resistance in cross-sectional research. However, it is unclear whether adiponectin predicts future body composition and insulin resistance.<bold>Objective: </bold>We aimed to investigate the potential relationship between adiponectin concentration and future regional body fat distribution and insulin resistance.<bold>Design and Setting: </bold>This was a community-based prospective cohort study with 5 years of follow-up.<bold>Participants: </bold>A total of 218 Japanese Americans without diabetes (79 men, 139 women, mean age 51.7 ± 10.1 years) were assessed at baseline and after 5 years of follow-up.<bold>Main Outcome Measures: </bold>Abdominal visceral and subcutaneous fat area and thigh subcutaneous fat area were measured by computed tomography (CT). Insulin resistance was evaluated by homeostasis model assessment 2 of insulin resistance (HOMA2-IR). Plasma total adiponectin was measured by radioimmunoassay.<bold>Results: </bold>Baseline adiponectin was inversely associated with abdominal visceral fat area (P = 0.037) and HOMA2-IR (P = 0.002) at 5 years in a multiple linear regression model after adjustment for baseline traits (including age, sex, BMI, abdominal visceral fat area, abdominal subcutaneous fat area, thigh subcutaneous fat area, HOMA2-IR) and weight change. However, no association was seen between baseline adiponectin concentration and BMI or other CT-measured regional fat depots at 5 years.<bold>Conclusions: </bold>Low plasma adiponectin concentration independently predicted future abdominal visceral fat accumulation and increased insulin resistance in Japanese Americans.
- Subjects
ADIPOSE tissues; ASIANS; BODY weight; HUMAN body composition; COMPUTED tomography; INSULIN resistance; LONGITUDINAL method; BODY mass index; ADIPONECTIN
- Publication
Journal of Clinical Endocrinology & Metabolism, 2017, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2017-01703