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- Title
Synthesis, Crystal Structures and Urease Inhibition of N'-(2-Bromobenzylidene)-2-(4-mtrophenoxy) acetohydrazide and N'-(4-Nitrobenzylidene) -2-(4-nitrophenoxy)acetohydrazide.
- Authors
Gui-Hua Sheng; Xiang-Fei Chen; Jian Li; Jie Chen; Ying Xu; Yan-Wei Han; Ting Yang; Zhonglu You; Hai-Liang Zhu
- Abstract
Two new hydrazone compounds, N'-(2-bromobenzylidene)-2-(4-nitrophenoxy)acetohydrazide (1) and N'-(4-nitro- benzylidene)-2-(4-nitrophenoxy)acetohydrazide (2), were prepared and characterized by elemental analysis, IR, UV- Vis and ¹H NMR spectroscopy, and single-crystal X-ray diffraction. Compound 1 crystallizes in the monoclinic space group P21/n with unit cell dimensions of a = 5.3064(5) Å, b = 18.202(2) Å, c = 15.970(2) Å, β = 95.866(3)°, V = 1534.4(2) ų, Z = 4, R1 = 0.0457, and wR2 = 0.0975. Compound 2 crystallizes in the monoclinic space group P21/c with unit cell dimensions of a = 4.6008(7) Å, b = 14.451(2) Å, c = 23.296(3) Å, β = 93.620(2)°, V = 1545.8(4) ų, Z = 4, R1 = 0.0441, and wR2 = 0.0985. Structures of the compounds are stabilized by hydrogen bonds and π⋯ π interactions. The urease inhibitory activities of the compounds were studied. Both compounds show strong urease inhibitory activities, with IC50 values of 8.4 and 20.2 µM, respectively.
- Subjects
UREASE; HYDRAZONES; AZO compound synthesis; AZIDE derivatives; CRYSTAL structure; HYDROGEN bonding; X-ray diffraction; ULTRAVIOLET-visible spectroscopy
- Publication
Acta Chimica Slovenica, 2015, Vol 62, Issue 4, p940
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2015.1770