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- Title
Correlation of Hippocampal Glucose Oxidation Capacity and Interictal FDG-PET in Temporal Lobe Epilepsy.
- Authors
Vielhaber, Stefan; von Oertzen, Joachim H.; Kudin, Alexei F.; Schoenfeld, Ariel; Menzel, Christian; Biersack, Hans-Juergen; Kral, Thomas; Elger, Christian E.; Kunz, Wolfram S.
- Abstract
Summary: Purpose: Interictal [18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) demonstrates temporal hypometabolism in the epileptogenic zone of 60–90% of patients with temporal lobe epilepsy. The pathophysiology of this finding is still unknown. Several studies failed to show a correlation between hippocampal FDG-PET hypometabolism and neuronal cell loss. Because FDG is metabolized by hexokinase bound to the outer mitochondrial membrane, we correlated the glucose-oxidation capacity of hippocampal subfields obtained after surgical resection with the corresponding hippocampal presurgical FDG-PET activity. Methods: In 16 patients with electrophysiologically confirmed temporal lobe epilepsy, we used high-resolution respirometry to determine the basal and maximal glucose-oxidation rates in 400-μm-thick hippocampal subfields obtained after dissection of human hippocampal slices into the CA1 and CA3 pyramidal subfields and the dentate gyrus. Results: We observed a correlation of the FDG-PET activity with the maximal glucose-oxidation rate of the CA3 pyramidal subfields (rp = 0.7, p = 0.003) but not for the regions CA1 and dentate gyrus. In accordance with previous studies, no correlation of the FDG-PET to the neuronal cell density of CA1, CA3, and dentate gyrus was found. Conclusions: The interictal hippocampal FDG-PET hypometabolism in patients with temporal lobe epilepsy is correlated to the glucose-oxidation capacity of the CA3 hippocampal subfield as result of impaired oxidative metabolism.
- Subjects
SUGAR in the body; PHYSIOLOGICAL oxidation; HIPPOCAMPUS (Brain); POSITRON emission tomography
- Publication
Epilepsia (Series 4), 2003, Vol 44, Issue 2, p193
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1046/j.1528-1157.2003.38102.x