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- Title
Fast and sensitive protein alignment using DIAMOND.
- Authors
Buchfink, Benjamin; Xie, Chao; Huson, Daniel H
- Abstract
The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.
- Subjects
OPEN source software; AMINO acid sequence; METAGENOMICS
- Publication
Nature Methods, 2015, Vol 12, Issue 1, p59
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.3176