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- Title
Navigating Tumour Microenvironment and Wnt Signalling Crosstalk: Implications for Advanced Cancer Therapeutics.
- Authors
Peri, Shraddha Shravani; Narayanaa Y, Krithicaa; Hubert, Therese Deebiga; Rajaraman, Roshini; Arfuso, Frank; Sundaram, Sandhya; Archana, B.; Warrier, Sudha; Dharmarajan, Arun; Perumalsamy, Lakshmi R.
- Abstract
Simple Summary: The tumour microenvironment comprises cellular components and the extracellular matrix, which surround the core of cancer cells and play a vital role in their development. Among these components are various immune cells such as T-regulatory cells, dendritic cells, and tumour-infiltrating lymphocytes, as well as other cells such as adipocytes, endothelial cells, cancer-associated fibroblasts (CAFs), cancer stem cells, and neuroendocrine cells, among others. The Wnt signalling pathway is a central pathway involved in tumour development. This review explores the significance of Wnt signalling in the communication between cellular components within the tumour microenvironment. Understanding this signalling pathway opens up possibilities for modifying the tumour microenvironment, potentially leading to insights into tumour development and progression. Additionally, this review delves into Wnt inhibition and inhibitors and their potential application in cancer therapeutics. Cancer therapeutics face significant challenges due to drug resistance and tumour recurrence. The tumour microenvironment (TME) is a crucial contributor and essential hallmark of cancer. It encompasses various components surrounding the tumour, including intercellular elements, immune system cells, the vascular system, stem cells, and extracellular matrices, all of which play critical roles in tumour progression, epithelial–mesenchymal transition, metastasis, drug resistance, and relapse. These components interact with multiple signalling pathways, positively or negatively influencing cell growth. Abnormal regulation of the Wnt signalling pathway has been observed in tumorigenesis and contributes to tumour growth. A comprehensive understanding and characterisation of how different cells within the TME communicate through signalling pathways is vital. This review aims to explore the intricate and dynamic interactions, expressions, and alterations of TME components and the Wnt signalling pathway, offering valuable insights into the development of therapeutic applications.
- Subjects
TUMOR genetics; TUMOR treatment; DENDRITIC cells; FIBROBLASTS; CELL physiology; DRUG resistance; MACROPHAGES; CELLULAR signal transduction; CANCER; EPITHELIAL-mesenchymal transition; FAT cells
- Publication
Cancers, 2023, Vol 15, Issue 24, p5847
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers15245847