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- Title
Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems.
- Authors
Khan, Fazlurrahman; Jeong, Geum-Jae; Tabassum, Nazia; Kim, Young-Mog
- Abstract
Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes. Due to its ubiquity, most bacterial species possess a wide range of downstream receptors that has a binding affinity to c-di-GMP and elicit output responses. In eukaryotes, several enzymes and riboswitches operate as receptors that interact with c-di-GMP and transduce cellular or environmental signals. This review examines the functional variety of receptors in prokaryotic and eukaryotic systems that exhibit distinct biological responses after interacting with c-di-GMP. Evolutionary relationships and similarities in distance among the c-di-GMP receptors in various bacterial species were evaluated to understand their specificities. Furthermore, residues of receptors involved in c-di-GMP binding are summarized. This review facilitates the understanding of how distinct receptors from different origins bind c-di-GMP equally well, yet fulfill diverse biological roles at the interspecies, intraspecies, and interkingdom levels. Furthermore, it also highlights c-di-GMP receptors as potential therapeutic targets, particularly those found in pathogenic microorganisms. C5iF5BkbNAVqYPEX5S1oMB Video Abstract
- Subjects
GUANYLIC acid; CELL communication; PATHOGENIC microorganisms; RIBOSWITCHES; DRUG target
- Publication
Cell Communication & Signaling, 2023, Vol 21, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-023-01263-5