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- Title
Challenging clinical cases in HCV infection.
- Authors
Strazzulla, Alessio; Matera, Giovanni; Mammone, Selma Valerie; Vaccaro, Vittoria; Pisani, Vincenzo; Costa, Chiara; Manti, Francesco; Doldo, Patrizia; Cosco, Lucio; Quintieri, Francesco; Cesario, Francesco; Liberto, Maria Carla; Giancotti, Aida; Torti, Carlo; Focà, Alfredo
- Abstract
We present clinical cases, which underline some difficulties in diagnosis and treatment of hepatitis C virus (HCV) infection. Case report #1 shows a patient who avoided clinical follow-up for HCV until the development of hepatocellular carcinoma. In this patient, non-invasive procedures did not allow to make a differential diagnosis between hydatidosis and hepatocellular carcinoma but diagnosis was only made with liver biopsy. In the case report #2, 24-week treatment with peg-interferon α2 and ribavirin was successfully administered to a HCV genotype-1b infected patient. Shortening HCV treatment did not impair sustained virological response, probably because HCV RNA was low (< 200,000 IU/l) at baseline. Lastly, a case series of patients (#3-6) with hemoglobinopathies is described. Sustained virological response after peg-interferon α2 and ribavirin was achieved in 2 out of 4 patients. While no severe treatment limiting hematological effects were encountered, patients needed more frequent blood transfusions. Thus, new anti-HCV schemes without peg-interferon and ribavirin are urgently needed.
- Publication
BMC Infectious Diseases, 2014, Vol 14, Issue 1, pS7
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/1471-2334-14-S5-S7