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- Title
Recent endemic coronavirus infection is associated with less-severe COVID-19.
- Authors
Sagar, Manish; Reifler, Katherine; Rossi, Michael; Miller, Nancy S.; Sinha, Pranay; White, Laura F.; Mizgerd, Joseph P.
- Abstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
- Subjects
COVID-19; ENDEMIC diseases; SARS virus; SARS-CoV-2; RESPIRATORY infections
- Publication
Journal of Clinical Investigation, 2021, Vol 131, Issue 1, p1
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI143380