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- Title
The gut microbiota and graft-versus-host disease.
- Authors
Fredricks, David N.
- Abstract
Graft-versus-host disease (GvHD) is a common complication of hematopoietic cell transplantation that negatively impacts quality of life in recipients and can be fatal. Animal experiments and human studies provide compelling evidence that the gut microbiota is associated with risk of GvHD, but the nature of this relationship remains unclear. If the gut microbiota is a driver of GvHD pathogenesis, then manipulation of the gut microbiota offers one promising avenue for preventing or treating this common condition, and antibiotic stewardship efforts in transplantation may help preserve the indigenous microbiota and modulate immune responses to benefit the host.
- Subjects
GUT microbiome; GRAFT versus host disease; IMMUNE response; HEMATOPOIETIC stem cell transplantation; TUMOR treatment; FERRANS &; Powers Quality of Life Index; INFLAMMATION; IMMUNOLOGY technique; QUALITY of life; RESEARCH funding; TUMORS; MICE; ANIMALS; DISEASE complications
- Publication
Journal of Clinical Investigation, 2019, Vol 129, Issue 5, p1808
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI125797