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- Title
A comprehensive pathway map of epidermal growth factor receptor signaling.
- Authors
Oda, Kanae; Matsuoka, Yukiko; Funahashi, Akira; Kitano, Hiroaki
- Abstract
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper,we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).
- Subjects
EPIDERMAL growth factor; MOLECULAR biology; GROWTH factors; GENE mapping; GENETIC transduction; MOLECULE-molecule collisions
- Publication
Molecular Systems Biology, 2005, Vol 1, Issue 1, pE1
- ISSN
1744-4292
- Publication type
Article
- DOI
10.1038/msb4100014