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- Title
Radiolabeled Nanogels for Nuclear Molecular Imaging.
- Authors
Möller, Martin; Singh, Smriti; Bingöl, Bahar; Morgenroth, Agnieszka; Schmaljohann, Jörn; Mottaghy, Felix M.
- Abstract
An efficient and simple synthesis approach to form stable 68Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 ± 50 nm. The radionuclide 68Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these 68Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.
- Subjects
NANOGELS; RADIOACTIVE tracers; GALLIUM chelates; IMAGING systems in biology; POLYETHYLENE glycol; DRUG delivery systems; POLYMERS; THERAPEUTICS
- Publication
Macromolecular Rapid Communications, 2013, Vol 34, Issue 7, p562
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201200744