We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structurally Stable Attractive Nanoscale Emulsions with Dipole-Dipole Interaction-Driven Interdrop Percolation.
- Authors
Shin, Kyounghee; Gong, Gyeonghyeon; Cuadrado, Jonas; Jeon, Serim; Seo, Mintae; Choi, Hong Sung; Hwang, Jae Sung; Lee, Youngbok; Fernandez‐Nieves, Alberto; Kim, Jin Woong
- Abstract
This study introduces an extremely stable attractive nanoscale emulsion fluid, in which the amphiphilic block copolymer, poly(ethylene oxide)- block-poly( ϵ-caprolactone) (PEO- b-PCL), is tightly packed with lecithin, thereby forming a mechanically robust thin-film at the oil-water interface. The molecular association of PEO- b-PCL with lecithin is critical for formation of a tighter and denser molecular assembly at the interface, which is systematically confirmed by T2 relaxation and DSC analyses. Moreover, suspension rheology studies also reflect the interdroplet attractions over a wide volume fraction range of the dispersed oil phase; this results in a percolated network of stable drops that exhibit no signs of coalescence or phase separation. This unique rheological behavior is attributed to the dipolar interaction between the phosphorylcholine groups of lecithin and the methoxy end groups of PEO- b-PCL. Finally, the nanoemulsion system significantly enhances transdermal delivery efficiency due to its favorable attraction to the skin, as well as high diffusivity of the nanoscale emulsion drops.
- Subjects
BLOCK copolymers; LECITHIN; NANOSTRUCTURED materials; NANOFLUIDS; DIPOLE-dipole interactions; PERCOLATION
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 18, p4292
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201604722