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- Title
Chemical Profiles and Bioactivities of Ethanol and Water Extracts of Sclerotium and Fruiting Body of Lignosus rhinocerotis (Cooke) from Banggai Islands, Indonesia.
- Authors
Timotius, Kris H.; Santoso, Adit W.; Simamora, Adelina
- Abstract
Lignosus rhinocerotis (tiger milk mushroom), a sclerotium-forming mushroom, has been shown to have various pharmacological properties. However, its chemical constituents were not much investigated. In addition, its enzymes' inhibitory potentials are not yet described. Hence, the study aimed to investigate the chemical compositions of its sclerotium and fruiting body. The UPLC-QTOF-MS/MS was used to analyze ethanol and water extracts of both sclerotium and fruiting bodies. The ethanol extracts of the sclerotium and fruiting body were investigated for their antioxidant (DPPH and phosphomolybdenum) and enzymes (a-glucosidase, xanthine oxidase, and trypsin) inhibitory activities. The UPLC-QTOF-MS/MS analyses showed the presence of adenosine, chelidimerine, and pingpeimine B in the water extracts of the sclerotium and the fruiting body. Whereas cytidine, feroxin A, hirsuteine, mangiferin, neomangiferin and sophoraisoflavone A were identified in ethanol extracts of the sclerotium and the fruiting body. The fruiting body showed higher phenolic content than the sclerotium. The fruiting body also exhibited relatively higher radical scavenging and reducing activities, as well as a-glucosidase inhibition activities, when compared with the sclerotium. However, both the sclerotium and the fruiting body showed slight xanthine oxidase (compared to allopurinol) and trypsin inhibition activities. Findings provide a basis for further exploration of phytotherapeutic applications of L. rhinocerotis.
- Subjects
BANGGAI Archipelago (Indonesia); ETHANOL; SCLEROTIUM (Genus); ANTIOXIDANTS; POLYPORACEAE
- Publication
Tropical Journal of Natural Product Research, 2022, Vol 6, Issue 12, p1975
- ISSN
2616-0684
- Publication type
Article
- DOI
10.26538/tjnpr/v6i12.13