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- Title
Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women.
- Authors
Fremann D; Linseisen J; Wolfram G; Fremann, Dorothee; Linseisen, Jakob; Wolfram, Günther
- Abstract
<bold>Objective: </bold>The habitual intake of the conjugated linoleic acid (CLA) isomer C18:2 c9t11 (rumenic acid, RA) was assessed and compared with plasma biomarkers.<bold>Design: </bold>The newly developed food-frequency questionnaire (FFQ) comprised 46 food items and was validated by means of a 7-day estimated record (7-d ER). Additionally, the dietary intake results of the FFQ, 7-d ER, the last day (1-d ER) and the last two days (2-d ER) before blood sampling of the 7-d ER were compared to the content of C18:2 c9t11 in plasma phospholipids (PL) and triglycerides (TG) as possible biomarkers.<bold>Setting: </bold>Metabolic unit of a university institute.<bold>Subjects: </bold>Fifty-seven students completed both dietary instruments. From all participants fasting blood samples were taken.<bold>Results: </bold>Mean daily intake of rumenic acid was 246 mg day(-1) and 323 mg day(-1) as measured by the FFQ and the 7-d-ER, respectively. The degree of correspondence between both assessment methods was acceptable; this is indicated by a total kappa value of kappa = 0.31 (P < 0.01) and a Pearson correlation coefficient of r = 0.46 (P < 0.01). Rumenic acid content in plasma triglycerides was twice as high as found in phospholipids. The correlation between the intake results gained with the 7-d ER and the plasma PL contents of C18:2 c9t11 was statistically significant; this was also true for the C18:2 c9tl 1 values in plasma TG compared with the intake results of one or two days before blood sampling.<bold>Conclusions: </bold>Regarding RA intake, the FFQ data revealed an acceptable degree of correspondence with the 7-d ER data but failed to show significant correlations to the potential biomarkers. However, with respect to the results of the 7-d ER, the RA content in plasma PL and TG are possible biomarkers of short-term and medium-term intake, respectively.
- Publication
Public Health Nutrition, 2002, Vol 5, Issue 1, p73
- ISSN
1368-9800
- Publication type
journal article
- DOI
10.1079/phn2001238