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- Title
HIV vaccine design and the neutralizing antibody problem.
- Authors
Burton, Dennis R.; Desrosiers, Ronald C.; Doms, Robert W.; Koff, Wayne C.; Kwong, Peter D.; .Moore, John P.; Nabel, Gary J.; Sodroski, Joseph; Wilson, Ian A.; Wyatt, Richard T.
- Abstract
Describes approaches to overcoming the problem of eliciting neutralizing antibodies (NAB) to HIV. Neutralization of isolates of HIV-1 from different genetic subtypes by reactive human monoclonal antibodies; Role of the V3 loop of gp120 in virus neutralization; Coreceptor sites as NAB target; Implications for HIV vaccine design.
- Subjects
HIV; HIV antibodies; MONOCLONAL antibodies; AIDS vaccines; IMMUNOGLOBULINS; IMMUNOGENETICS
- Publication
Nature Immunology, 2004, Vol 5, Issue 3, p233
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni0304-233