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- Title
Descending serotonergic and noradrenergic systems do not regulate the antipruritic effects of cannabinoids.
- Authors
Todurga, Zeynep Gizem; Gunduz, Ozgur; Karadag, Cetin Hakan; Ulugol, Ahmet
- Abstract
BackgroundFor centuries, cannabinoids have been known to be effective in pain states. Itch and pain are two sensations sharing a lot in common.ObjectiveThe goal of this research was to observe whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behaviour and whether neurotoxic destruction of descending serotonergic and noradrenergic pathways mediate the antipruritic effect of WIN 55,212-2.Material and methodsScratching behaviour was induced by intradermal injection of serotonin (50 µg/50 µl/mouse) to Balb/c mice. The neurotoxins 5,7-dihydroxytryptamine (5,7-DHT, 50 μg/mouse) and 6-hydroxydopamine (6-OHDA, 20 μg/mouse) are applied intrathecally to deplete serotonin and noradrenaline in the spinal cord. WIN 55,212-2 (1, 3, 10 mg/kg, i.p.) dose-dependently attenuated serotonin-induced scratches. Neurotoxic destruction of neither the serotonergic nor the noradrenergic systems by 5,7-DHT and 6-OHDA, respectively, had any effect on the antipruritic action of WIN 55,212-2.ConclusionOur findings indicate that cannabinoids dose-dependently reduce serotonin-induced scratching behaviour and neurotoxic destruction of descending inhibitory pathways does not mediate this antipruritic effect.
- Subjects
CANNABINOIDS; SEROTONINERGIC mechanisms; NORADRENERGIC mechanisms; ANTIPRURITICS; PAIN management; INTRADERMAL injections; THERAPEUTICS
- Publication
Acta Neuropsychiatrica, 2016, Vol 28, Issue 6, p321
- ISSN
0924-2708
- Publication type
Article
- DOI
10.1017/neu.2016.16