We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preparation of Hydroxypropyl Methylcellulose Acetate Succinate with a Narrow Molecular Weight Dispersion.
- Authors
Liangliang Zhang; Shiyu Fu
- Abstract
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) was successfully synthesized from the reaction of hydroxypropyl methylcellulose with succinic anhydride and acetic anhydride in an acetone/pyridine system. Products with different contents of succinyl groups and acetyl groups were prepared by varying the reaction conditions. In the acetone/pyridine system, equipment corrosion does not occur, the product is easy to wash, and the solvent can be recycled. By varying the concentration of the esterifying agents, products with different ratios of acidic groups can be obtained. Under the optimum conditions, the obtained products had an average molecular weight between 5.39×104 and 5.41×104, a number average molecular weight from 4.97×104 to 5.13×104, and a polydispersity index from 1.05 to 1.08. The products dissolved well in acetone and methanol, and formed films on a mold. The films had good pH-sensitivity, tensile strength, and thermal stability. The formed films could dissolve in solutions with a pH value ranging from 5.4 to 6.4, and are therefore suitable for use as an enteric coating for pharmaceutical dosage forms.
- Subjects
MOLECULAR weights; METHYLCELLULOSE; DOSAGE forms of drugs; ACETYL group; ACETONE; DISPERSION (Chemistry); ACETIC anhydride
- Publication
Paper & Biomaterials, 2020, Vol 5, Issue 4, p36
- ISSN
2096-2355
- Publication type
Article
- DOI
10.12103/j.issn.2096-2355.2020.04.005