Pancreatic cancer has the 12th incidence rate in the world. This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy. In this presentation, we mention the histological types of pancreatic cancer, the importance of systemic therapy for operable cases (pre- and post-surgery), and of chemotherapy for advanced and metastatic cancer. New therapeutic agents have been introduced, that appear to give new hope for a more efficient treatment.