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- Title
Synthesis and Evaluation of the Antibacterial and Antitubercular Activity of Some N<sup>1</sup>-Aral-N<sup>4</sup> -(3-Chloro-4-fluoro-phenyl) thiosemicarbazones and their Copper(I) Complexes.
- Authors
Khazi, Imtiyazahmed M.; Koti, Rajesh S.; Chadha, Monica V.; Mahajanshetti, Channabasappa S.; Gadad, Andanappa K.
- Abstract
New N¹-aral-N4-(3-chloro-4-fluoro-phenyl) thiosemicarbazones (2a-h) and their Cu(I) complexes (3a-h) have been prepared and characterized by elemental analysis and spectral methods (IR and ¹H-NMR). Thiosemicarbazones 2a-h bind to copper(I) as bidentate ligand via nitrogen and thione sulphur centers to afford 3a-h. Both ligands and their complexes are screened against Eschericchia coli (National Collection of Type Culture 10418) and Staphylococcus aureus (National Collection of Type Culture 5571) to evaluate their antibacterial properties and against human virulent H37Rv strain of Mycobacterium tuberculusis for their antitubercular properties. Ligands 2d-h showed promising antibacterial activity while their Cu(I) complexes 3d-h exhibited excellent activity. The compounds 2a, 2d, 2f, 2g and their Cu(I) complexes 3a, 3d, 3f, and 3g were evaluated for their antitubercular activity. It was observed that compounds 2a, 2g, 3a, 3d showed moderate activity while 3f and 3g exhibited promising antibubercular activity.
- Subjects
THIOSEMICARBAZONES; ANTIBACTERIAL agents; ANTI-infective agents; AMINES; PHENOLS; ORGANOSULFUR compounds
- Publication
Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften), 2005, Vol 55, Issue 2, p107
- ISSN
0004-4172
- Publication type
Article