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- Title
P21 Gene Variation and Late-Onset Alzheimer's Disease in the Italian Population.
- Authors
Scacchi, R.; Gambina, G.; Moretto, G.; Corbo, R.M.
- Abstract
Background: Variation at the cyclin-dependent kinase inhibitor gene P21 in a patient sample of the Italian population was investigated in search of genetic factors potentially involved in sporadic late-onset Alzheimer's disease (AD). Methods: Two single nucleotide polymorphisms (SNPs) were studied in this gene: a C>A transversion at codon 31 (ser>arg) in exon 2 (RS1801270) and a C>T transition occurring 20 bp downstream from the stop codon of exon 3 (RS1059234). Results: The odd ratios were: RS1801270 A allele = 0.62 (95% CI = 0.33-1.18; p = 0.14); RS1059234 T allele = 0.57 (95% CI = 0.33-0.98; p = 0.04). In addition, a longer duration of disease was found with genotypes carrying the RS1059234 T allele (4.3 ± 2.5 years) than with those not carrying it (3.3 ± 2.1 years) (p = 0.001). Conclusion: In the present sample, one of the two SNPs seems in some way related to AD, since carriers of one allele were slightly protected against AD onset. Copyright © 2013 S. Karger AG, Basel
- Subjects
ITALY; GENETICS of Alzheimer's disease; AGE factors in disease; ALLELES; ANALYSIS of variance; BLOOD testing; CHI-squared test; COMPARATIVE studies; CONFIDENCE intervals; EPIDEMIOLOGY; GENES; GENETIC polymorphisms; GENETIC techniques; NEUROPSYCHOLOGICAL tests; POPULATION geography; PROTEIN kinases; RESEARCH funding; LOGISTIC regression analysis; DATA analysis; CONTROL groups; DISEASE duration; DESCRIPTIVE statistics
- Publication
Dementia & Geriatric Cognitive Disorders, 2013, Vol 35, Issue 1/2, p51
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000345788