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- Title
Pain and Intramuscular Release of Algesic Substances in the Masseter Muscle After Experimental Tooth-Clenching Exercises in Healthy Subjects.
- Authors
Dawson, Andreas; Ghafouri, Bijar; Gerdle, Bjö'rn; List, Thomas; Svensson, Peter; Ernberg, Malin
- Abstract
Aims: To investigate whether experimental tooth clenching leads to a release of algesic substances in the masseter muscle. Methods: Thirty healthy subjects (16 females, 14 males) participated. During two sessions, separated by at least 1 week, intramuscular microdialysis was performed to collect masseter muscle 5-hydroxytryptamine (5-HT) and glutamate as well as the metabolic markers pyruvate and lactate. Two hours after the start of microdialysis, participants were randomized to a 20-min repetitive experimental tooth-clenching task (50% of maximal voluntary contraction) or a control session (no clenching). Pain and fatigue were measured throughout. The Friedman and Wilcoxon tests were used for statistical analyses. Results: No alterations were observed in the concentrations of 5-HT, glutamate, pyruvate, and lactate over time in the clenching or control session, or between sessions at various time points. Pain (P < .01) and fatigue (P < .01) increased significantly over time in the clenching session and were significantly higher after clenching than in the control session (P < .01). Conclusion: Low levels of pain and fatigue developed with this experimental tooth-clenching model, but they were not associated with an altered release of 5-HT, glutamate, lactate, or pyruvate. More research is required to elucidate the peripheral release of algesic substances in response to tooth clenching.
- Subjects
BRUXISM; CROSSOVER trials; FATIGUE (Physiology); RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); TEMPOROMANDIBULAR disorders; U-statistics; DATA analysis; PAIN measurement; DATA analysis software; DESCRIPTIVE statistics
- Publication
Journal of Orofacial Pain, 2013, Vol 27, Issue 4, p350
- ISSN
1064-6655
- Publication type
Article
- DOI
10.11607/jop.1170