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- Title
Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice.
- Authors
Lee, Jinhee; Jang, Soyoung; Choi, Minjee; Kang, Mincheol; Lim, Su-Geun; Kim, SI-Yong; Jang, Soyeon; Ko, Jiwon; Kim, Eungyung; Yi, Junkoo; Choo, Yeonsik; Kim, Myoung Ok; Ryoo, Zae Young
- Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-α, which leads to an autoimmune reaction and exacerbates lupus-like symptoms.
- Subjects
CATHEPSINS; PROTEIN expression; SYSTEMIC lupus erythematosus; TOLL-like receptors; INTERFERONS; LABORATORY mice
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-94855-5