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- Title
Drug‐drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.
- Authors
Yoshikawa, Naoki; Tazaki, Tomoya; Hatanaka, Mari; Oda, Yasuharu; Matsumoto, Nobuhiro; Sonoda, Junichiro; Ikeda, Ryuji
- Abstract
Summary: What is known and objective: Multi‐drug combinations often make chemotherapy difficult owing to drug‐drug interactions (DDIs). We report a rare and difficult‐to‐treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description: A 70‐year‐old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment. What is new and Conclusion: We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.
- Subjects
JAPAN; ANTICONVULSANTS; MYCOBACTERIAL disease diagnosis; PHENOBARBITAL; DRUG interactions; EPILEPSY; MEDICAL prescriptions; MYCOBACTERIAL diseases; MYCOBACTERIUM avium; PHENYTOIN; THERAPEUTICS
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2019, Vol 44, Issue 1, p119
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/jcpt.12764