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- Title
Giving protein traffic the green light.
- Authors
Hendershot, Linda M.
- Abstract
Most proteins that are secreted or expressed on a cell surface are synthesized on membrane polysomes and enter the endoplasmic reticulum (ER) as unfolded polypeptide chains. A complex series of interactions with resident enzymes and molecular chaperones ensure that these proteins are folded and assembled to achieve their correct tertiary structures before being transported to the Golgi and along the secretory pathway. However, the mechanism by which properly folded molecules are sorted from incompletely or improperly folded proteins and from the resident proteins that guide this process remains unclear.
- Subjects
PROTEINS; CELL membranes; ENDOPLASMIC reticulum; PEPTIDES
- Publication
Nature Cell Biology, 2000, Vol 2, Issue 6, pE105
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/35014100