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- Title
A Retrospective Study of Patients Treated With Oral and Injectable Anticancer Medications: Evaluation of Hospital Outcomes.
- Authors
Agafonova, Julia A.; Snegovoy, Anton V.; Omelyanovskiy, Vitaly V.
- Abstract
Background: The use of oral and injectable forms of drugs in patients with malignancies is predominantly performed as outpatient care. This approach improves the quality of patients' life as long as the necessary safety aspects are respected. The results of the study should help to decide whether such forms of medications can be transferred from the daycare center and whether patients can be safely managed at home. Objective: To analyze the hospitalization outcomes of patients who received oral or injectable medications at daycare centers. Methods: A retrospective secondary data analysis was conducted using a data set including the hospitalizations of cancer patients with the oral, injectable, or a combination of oral and injectable anticancer drugs from outpatient departments of the medical centers of the Russian Federation in 2021. The primary end point of the study was the hospitalization outcomes. Daycare hospital discharge was defined as a favorable outcome. Adverse outcomes of hospitalization included treatment interruption, transfer of patients to inpatient care (hospital care), and patient's death. Results: The study included 261,591 hospitalizations. The median age of the patients was 66 (57-73) years. The study group consisted of 48.1% men and 51.9% women. The most frequent malignant neoplasms in the study group were breast cancer (33.0%), prostate cancer (30.6%), and renal cancer (7.6%). Oral medications were used in 48.0%, injectables in 43.0%, and the combination of oral drugs and injectables in 9.1% of patients. In 98.6% of cases, there was a daycare hospital discharge. Adverse outcomes, such as treatment interruption or transfer of patients to inpatient care were found in 1.2% (95% CI, 1.1-1.2) and 0.2% (95% CI, 0.2-0.2), respectively. Patient death occurred in 4 hospitalizations (oral medication group). A significant association was noted when analyzing the adverse outcome of hospitalization depending on how the drug had been administered. Conclusion: Currently, such strategies as the specialized oral therapy centers and the anticancer drug management programs are actively implemented for the patients under study. The results suggest the relative safety of the oral and injectable forms of the anticancer drugs in most cases. The findings support a home-based management strategy for these patients, subject to further identification of risk groups for adverse outcomes.
- Subjects
TEXAS; THERAPEUTIC use of antineoplastic agents; HOSPITALS; INJECTIONS; ADULT day care; ORAL drug administration; CONFERENCES &; conventions; TREATMENT effectiveness; TUMORS; EVALUATION
- Publication
Journal of Oncology Navigation & Survivorship, 2023, Vol 14, Issue 11, p366
- ISSN
2166-0999
- Publication type
Article