We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Candidatus Rickettsia tarasevichiae Infection in Eastern Central China: A Case Series.
- Authors
Wei Liu; Hao Li; Qing-Bin Lu; Ning Cui; Zhen-Dong Yang; Jian-Gong Hu; Ya-Di Fan; Chen-Tao Guo; Xiao-Kun Li; Ya-Wei Wang; Kun Liu; Xiao-Ai Zhang; Lan Yuan; Pu-Yu Zhao; Shu-Li Qin; Wu-Chun Cao; Liu, Wei; Li, Hao; Lu, Qing-Bin; Cui, Ning
- Abstract
<bold>Background: </bold>Human infection with Candidatus Rickettsia tarasevichiae (CRT) was first reported in northeastern China in 2012.<bold>Objective: </bold>To describe the clinical spectrum and laboratory findings of patients infected with CRT in eastern central China.<bold>Design: </bold>Case series.<bold>Setting: </bold>A sentinel hospital for severe fever with thrombocytopenia syndrome (SFTS) in eastern central China in 2014.<bold>Participants: </bold>Hospitalized patients with SFTS-like illness.<bold>Measurements: </bold>Molecular and serologic tests were performed to diagnose CRT infection. Data about clinical manifestations and laboratory findings were retrieved from medical records.<bold>Results: </bold>56 of 733 assessed patients had CRT based on polymerase chain reaction and sequencing. All patients presented with nonspecific manifestations, including fever (96%), malaise (88%), myalgia (57%), cough (25%), and dizziness (14%). Only 2 patients had rash. Further, 16% had eschar, 29% had lymphadenopathy, 100% had gastrointestinal symptoms, 34% had neurologic symptoms, 43% had hemorrhagic manifestations, and 23% had signs of plasma leakage. Thrombocytopenia was observed in 70%, leukopenia in 59%; lymphopenia in 45%; and elevated levels of lactate dehydrogenase in 82%, aspartate aminotransferase in 70%, alanine aminotransferase in 54%, and creatinine kinase in 46%. Co-infection with SFTS virus was documented in 66% patients, and 8 of the 56 patients died.<bold>Limitations: </bold>Patients with CRT were not treated for infection because they were retrospectively identified. This was not a population-based study, and the results cannot be generalized to all patients with CRT.<bold>Conclusion: </bold>Candidatus R tarasevichiae infection should be considered in the differential diagnosis of febrile patients with SFTS-like illness in endemic areas.<bold>Primary Funding Source: </bold>National Natural Science Foundation of China.
- Subjects
CHINA; RICKETTSIA; PUBLIC health &; society; CANDIDATUS diseases; MEDICAL microbiology; INTERNAL medicine; PATIENT compliance; RICKETTSIAL disease diagnosis; CROSS infection; DIFFERENTIAL diagnosis; ENZYME-linked immunosorbent assay; BIOLOGICAL evolution; FLUORESCENT antibody technique; POLYMERASE chain reaction; RICKETTSIAL diseases; RNA viruses; COMORBIDITY; RETROSPECTIVE studies; REVERSE transcriptase polymerase chain reaction; RNA virus infections; DIAGNOSIS
- Publication
Annals of Internal Medicine, 2016, Vol 164, Issue 10, p641
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/M15-2572