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- Title
A Metastatic Neuroblastoma with Long Survival in Adolescence.
- Authors
SAWADA, TADASHI; TODO, SHINJIRO; NAKAJIMA, FUMIAKI; TANAKA, TERUFUSA; FUJITA, KATSUTOSHI; TOZAWA, MUTSUHIKO; AMANO, TADAHARU; KUSUNOKI, TOMOICHI
- Abstract
We report a 16-year 8-month-old girl with neuroblastoma (stage III) who received surgery for abdominal masses four times during a 52-month period. She is now treated with oral administration of cyclophosphamide (2 mg/kg) and is in good condition even though she has several metastatic lesions.In this paper, we consider why a 16-year-old girl with a tumor of estimated stage III has had a long survival period of 52 months. There seem to be three interesting points related to her long survival. The first is that the tumor response to the treatments was good, particularly to a large dose of cyclophosphamide. The second is the histological observation of the tumor specimens obtained at four different occasions from the same or different portions. The immature tumor cells of the primary tumor changed to ganglioneuroma during the first 30-month period, but the newly appearing metastatic lymphnodes were histologically neuroblastoma. The third is her immunological condition during treatment. The fact that her nonspecific humoral and cellular immune competence remained in good condition seems to be a factor favorable for her good prognosis.
- Publication
Japanese Journal of Clinical Oncology, 1979, Vol 9, Issue 1, p169
- ISSN
0368-2811
- Publication type
Article