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- Title
Studies on the Mechanism of Hypoproteinemia in Gastric Cancer.
- Authors
YAMAOKA, KATSUHIKO; NOGUCHI, SADAO; HIGASHI, HIROMU; JINNAI, DENNOSUKE
- Abstract
In a previous paper, we reported that the leakage of serum albumin into the gastric juice definitely increased in six out of 30 patients suffering from gastric cancer and discussed the mechanisms of albumin leakage into the stomach lumen.In this study, we measured the leakage of scrum albumin into the gastric juice of rats with gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Nine through 12 months after the beginning of MNNG administration, several rats began to show adenocarcinoma in the glandular stomach. Albumin leakage of these rats increased notably compared to non-tumor-developing rats. In the 15th month, all the rats were afflicted with gastric cancer, accompanied by a high leakage of serum albumin.To study the mechanism of albumin leakage, leakage of serum albumin into the gastric juice was measured in rats which had undergone various treatments, such as thoracic duct ligation, subcutaneous transplantation of Yoshida sarcoma, administration of toxohormone and experimental ulccration of the stomach. The rats which were given thoracic duct ligation or those which were administered toxohormone all showed mild increase in the leakage of serum albumin, and a significant increase in the leakage was detected in rats bearing subcutaneously transplanted Yoshida sarcoma nine or more days after transplantation. On the other hand, the leakage scarcely increased in the rats with experimental gastric ulcer.From these results, we considered that the causes of albumin leakage into the gastric juice in cases with gastric cancer can be attributed not only to the local changes of the gastric wall but also to a systemic phenomenon associated with the tumor-bearing host.
- Publication
Japanese Journal of Clinical Oncology, 1974, Vol 4, Issue 2, p105
- ISSN
0368-2811
- Publication type
Article