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- Title
The scientific career and life of Edmond H. Fischer—A personal tribute.
- Authors
Cohen, Philip
- Abstract
Eddy and Ed discussed why glycogen phosphorylase from potatoes did not require 5'-AMP for activity and what the difference might be between phosphorylase I a i and I b i and decided to take a crack at the problem. The Cori's reasoned (incorrectly as it turned out) that phosphorylase I a i probably contained tightly bound 5'-AMP and that another enzymatic activity they had detected, probably converted phosphorylase I a i to phosphorylase I b i by catalysing the removal of 5'-AMP. Abbreviations ATP adenosine trisphosphate cyclic AMP 3'5'-cyclic adenosine monophosphate EGTA 3,12-Bis(carboxymethyl)-6,8-dioxa-3,12-diazatetradecane-1,14-dioic acid IUBMB International union of biochemistry and molecular biology KAF Kinase activating factor PhD Doctor of philosophy UK United kingdom 5'AMP 5' adenosine monophosphate I am delighted to have been invited to write the introductory article of this special issue of IUBMB Life on Protein Phosphorylation dedicated to Edmond Henri Fischer, known simply as Eddy to all his friends, who died on 27 August 2021, at the age of 101. THE IDENTIFICATION OF PROTEIN TYROSINE PHOSPHATASES Soon after their seminal discovery, Eddy and Ed agreed that one of them should focus on phosphorylase kinase (Ed Krebs) and the other on phosphorylase phosphatase (Eddy Fischer).
- Subjects
PHOSPHORYLASES; EPIDERMAL growth factor receptors; CYCLIC-AMP-dependent protein kinase; CALCIUM-binding proteins; NOBEL Prize in Physiology or Medicine
- Publication
IUBMB Life, 2023, Vol 75, Issue 4, p284
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.2695