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- Title
RNA Splicing in Cancer and Targeted Therapies.
- Authors
Islam, Md Rafikul; Nagar, Preeti; Neetole, Shegufta Tasneem; Wan, Ledong; Rahman, Mohammad Alinoor
- Abstract
This document, titled "RNA Splicing in Cancer and Targeted Therapies," discusses the role of RNA splicing in gene expression and proteome diversity, particularly in relation to cancer. The document highlights the interplay between splicing and other steps in mRNA metabolism, as well as the implications of splicing alterations in tumorigenesis. It also explores the potential for targeted therapies that focus on RNA splicing in cancer treatment. The document acknowledges the challenges in identifying tumorigenic RNA isoforms and discusses various therapeutic modalities in development. Overall, the document emphasizes the importance of continued research in RNA splicing and its potential for advancing cancer therapeutics.
- Subjects
RNA splicing; CANCER treatment; GENETIC engineering; GENE expression; CIRCULAR RNA
- Publication
Genes, 2023, Vol 14, Issue 11, p2020
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes14112020