This study primarily aims to explore how and with the help of what ideas scientific thought has transformed in the works of Nicholas of Cusa. This subject will be carried to the history of science and to that of philosophy in Turkey with critical examination of İdris Küçükömer and Hilmi Ziya Ülken. Besides these associations, the influence of Cusa on philosophy, mathematics, law, theology, political science, public adminstration, sociology and economic thought will also be discussed.