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- Title
Reconstruction of Mandibular Defects Using Bone Morphogenic Protein: Can Growth Factors Replace the Need for Autologous Bone Grafts? A Systematic Review of the Literature.
- Authors
Herford, Alan S.; Stoffella, Enrico; Tandon, Rahul
- Abstract
Autogenous bone is still considered the "gold standard" of regenerative and reconstructive procedures involving mandibular defects. However, harvesting of this material can lead tomany complications like increasing morbidity, expanding of the surgical time, and incomplete healing of the donor site. In the last few years many authors looked for the development of effective reconstruction procedures using osteoinductive factors without the need for conventional bone grafting. The first-in-human study involving the use of BoneMorphongenic Proteins (rhBMP) for mandibular reconstruction was performed in 2001 byMoghadam. Only few articles have been reported in the literature since then. The purpose of this study was to search and analyze the literature involving the use of rhBMP for reconstruction of mandibular defects. In all the studies reported, authors agree that the use of grown factors may represent the future of regenerative procedures with more research necessary for confirmation.
- Subjects
MANDIBLE abnormalities; DISEASES; BONE grafting; EXPERIMENTAL surgery; RESEARCH
- Publication
Plastic Surgery International, 2011, p1
- ISSN
2090-1461
- Publication type
Article
- DOI
10.1155/2011/165824