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- Title
Regenerative effect of Lignosus rhinocerus on a mouse model of peripheral neuropathy.
- Authors
Şeker, Ayşe; Taşpınar, Filiz; Oğuz, Elif Kaval; Üstün, Ramazan
- Abstract
Objective: Currently, there is no pharmacological agent to prevent or treat cisplatin-induced peripheral neuropathy. Medicinal mushroom have been recommended as natural remedies to increase the survival of patients in cancer treatment. This study aimed to investigate the regenerative effect of Lignosus rhinocerotis (L. rhinocerotis) on mouse model of peripheral neuropathy. Methods: A cold water extract of L. rhinoceros was prepared. BALB/c mice were divided into three groups as control (n=12), cisplatin (n=12) and cisplatin + L. rhinocerotis (n=12). Cisplatin and cisplatin + L. rhinocerotis groups were treated with cisplatin (2.4 mg/kg/day, total dose 24 mg/kg) to create a peripheral neuropathy model. The control group received same volume of saline. L. rhinocerotis extract was given intraperitoneally to the cisplatin + L. rhinocerotis group to treat peripheral neuropathy. To determine regenerative effects, it was measured body weight, peripheral nerve sensory function using thermal hyperalgesia and compound muscle action potential (CMAP) with electromyography (EMG) device. Results: Cisplatin caused significant loss of weight and sensory function in the experimental groups when compared to the control group (p<0.05). The sensory response rate of L. rhinocerotis-treated peripheral neuropathy animals to thermal hyperalgesia were significantly increased compared to the cisplatin group (p<0.05). In the electromyographic examination of the sciatic nerve and the gastrocnemius muscle, BKAP findings of the animals treated with L. rhinocerotis were significantly higher than the cisplatin group (p<0.05). However, there was no statistically significant difference concerning sensory function and CMAP findings between the control group and cisplatin + L. rhinocerotis group. Conclusion: L. rhinocerotis elicited regenerative effects in mice with peripheral neuropathy. This mushroom species may contain bioactive substances that are effective in the prevention and treatment of peripheral neuropathy. L. rhinocerotis should be further investigated as a potential therapeutic agent.
- Subjects
PERIPHERAL neuropathy; WEIGHT loss; MICE; SKELETAL muscle; SCIATIC nerve; NATUROPATHY; COLD-blooded animals
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2019, Vol 13, Issue S1, pS59
- ISSN
1307-8798
- Publication type
Article