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- Title
Expression of microRNA‐21 and TIMP‐3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
- Authors
Navarro, Raquel; Delgado‐Jiménez, Yolanda; Guinea‐Viniegra, Juan; Llamas‐Velasco, Mar; Daudén, Esteban
- Abstract
Background: Expression of microRNA‐21 (miR‐21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP‐3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFα) sheddase TACE (TNFα‐converting enzyme)/ADAM17. We described the profile of miR‐21 and TIMP‐3 in paradoxical psoriasiform reactions induced by anti‐TNFα drugs and in a control group to elucidate the pathogenesis of this reactions. Methods: We performed an analytic, cross‐sectional, prospective, experimental case‐control study. We compared our findings with those of non‐induced psoriasis. Results: We included 15 patients with a change of morphology (plaque to guttate psoriasis) and 10 patients with induced psoriasis (six palmoplantar pustulosis and four plaque psoriasis). Consecutive patients with different subtypes of non‐induced, non‐systemically treated psoriasis were included as a control group. We found that most cases with guttate psoriasis and with induced plaque psoriasis cases showed high expression of TIMP‐3 expression and decreased or poorly increased levels of miR‐21. The expression pattern was not homogeneous in the cases of induced palmoplantar pustulosis. These profiles differ from those of non‐induced psoriasis. Conclusion: We conclude that various pro‐inflammatory cytokine profiles are involved in the pathogenesis of paradoxical psoriasiform reactions and non‐induced psoriasis.
- Subjects
MICRORNA; MATRIX metalloproteinase inhibitors; TUMOR necrosis factors; NECROSIS
- Publication
Journal of Cutaneous Pathology, 2022, Vol 49, Issue 2, p116
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.14113