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- Title
Acquired elastotic hemangioma-like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus/prurigo nodularis-like lesions of the knee and elbow.
- Authors
Kacerovska, Denisa; Portelli, Francesca; Michal, Michal; Kazakov, Dmitry V.
- Abstract
Background The so-called acquired elastotic hemangioma ( AEH) represents a peculiar vascular lesion affecting the sun-damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle-aged or elderly women. Methods This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus ( LSC)/prurigo nodularis ( PN) with a marked subepidermal vascular proliferation closely resembling AEH. Results Microscopically, all cases of cutaneous lesions showed epithelial features of LSC/ PN, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Moreover, a marked subepidermal vascular proliferation arranged in a horizontal band closely resembling AEH was detected in these lesions. Another common histopathological finding was eccrine duct squamous metaplasia and/or hyperplasia. Conclusions While AEH represents a distinctive clinicopathological variant of hemangioma characteristically appearing on sun-exposed areas of middle-aged or elderly patients, the herein described lesions seem to be non-neoplastic epithelial, vascular and eccrine sweat duct reactive changes which are likely to be associated with chronic pressure or repeated mechanical stimulation with a marked predilection for the knee and elbow.
- Subjects
TISSUE wounds; ACANTHOSIS nigricans; METAPLASIA; HYPERPLASIA
- Publication
Journal of Cutaneous Pathology, 2017, Vol 44, Issue 7, p605
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.12945